Back to search

Article

Agricultural SDHIs Induce Azole Resistance in Aspergillus fumigatus via Mitochondrial Sdh1 Suppression

2025-05-05

Abstract excerpt

<title>Abstract</title> <p>Introduction: <italic>Aspergillus fumigatus</italic> poses significant clinical challenges due to its increasing azole resistance. This study investigates the <italic>sdh1</italic> gene's role in regulating azole susceptibility, mitochondrial function, and virulence. <h4>Materials and Methods:</h4> Fungal strains were co-cultured with varying concentrations of succinate dehydrogenase in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5bec8f7c-b674-56a4-ba63-597bfcb92a2b
DOI
10.21203/rs.3.rs-6487242/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Agricultural SDHIs Induce Azole Resistance in Aspergillus fumigatus via Mitochondrial Sdh1 SuppressionDOI 10.21203/rs.3.rs-6487242/v1
Succinate Dehydrogenase Inhibitors as Triggers of Azole Resistance in Aspergillus fumigatus: The Role of sdh1 and Efflux PathwaysSemantic proximity
Comparative analysis of the biological characteristics and mechanisms of azole resistance of clinical Aspergillus fumigatus strainsSemantic proximity
Pan-azole- and multi-fungicide-resistant <i>Aspergillus fumigatus</i> is widespread in the United StatesSemantic proximity
Elevated mutation rates in the multi-azole resistant <i>Aspergillus fumigatus</i> clade drives rapid evolution of antifungal resistanceSemantic proximity
Genomic Diversity of Azole-Resistant Aspergillus fumigatus in the United States.Semantic proximity
The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back.Semantic proximity
Phenotypic and Molecular Characterization of Three Clinical Voriconazole- Resistant Aspergillus fumigatus Isolates Harboring TR46/M143L Mutations in cyp51ASemantic proximity
Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance.Semantic proximity
Genomic epidemiology links azole-resistant <i>Aspergillus fumigatus</i> hospital bioaerosols to chronic respiratory aspergillosisSemantic proximity
The Transcriptome Response to Azole Compounds in Aspergillus fumigatus Shows Differential Gene Expression across Pathways Essential for Azole Resistance and Cell SurvivalSemantic proximity
Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanismSemantic proximity
Unveiling environmental transmission risks: comparative analysis of azole resistance in Aspergillus fumigatus clinical and environmental isolates from Yunnan, China.Semantic proximity
Select a neighboring publication to make it the new centre.