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Succinate Dehydrogenase Inhibitors as Triggers of Azole Resistance in Aspergillus fumigatus: The Role of sdh1 and Efflux Pathways

2024-12-19

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<title>Abstract</title> <p>Background <italic>Aspergillus fumigatus</italic> is a major cause of invasive aspergillosis in immunocompromised patients. The rise in antifungal resistance is linked to the use of succinate dehydrogenase inhibitors (SDHIs). Objective This study investigates the mechanism of acquired azole resistance in <italic>A. fumigatus</italic>, triggered by SDHIs, which are widely used agricult...

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Literature Corpus work
d5a402b4-4ad8-5984-9395-7602784c75d4
DOI
10.21203/rs.3.rs-5441096/v1
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