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Unraveling the Potential of Physical Activity and High-Intensity Interval Training in the Treatment of Familial Hypercholesterolemia: Impact on Cardiorespiratory Fitness, Atherosclerosis, and Underlying Mechanisms. Study protocol of the UPPA-FH Project

2025-12-29

Abstract excerpt

<h4>Introduction</h4> Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein -cholesterol (LDL-c) levels, increasing early cardiovascular risk. Many patients do not reach LDL-c targets despite treatment. Physical activity and exercise may help by improving cardiorespiratory fitness (CRF), reducing inflammation, and modulating metabolic pathways. This study aims...

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Literature Corpus work
5be5048c-642f-5fd6-9857-6112f2a639c5
DOI
10.64898/2025.12.22.25342692
Open publication

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Unraveling the Potential of Physical Activity and High-Intensity Interval Training in the Treatment of Familial Hypercholesterolemia: Impact on Cardiorespiratory Fitness, Atherosclerosis, and Underlying Mechanisms. Study protocol of the UPPA-FH ProjectDOI 10.64898/2025.12.22.25342692
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