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Article

Exploring gene-activity interplay in cardiovascular disease: is feasible to mitigate genetic risk through physical activity?

European journal of preventive cardiology - 18 Feb 2026

Núñez-Cortés Rodrigo, Joensuu Laura, López-Gil José Francisco, Calatayud Joaquín, Petermann-Rocha Fanny, Andersen Lars Louis, Sillanpää Elina, López-Bueno Rubén

Abstract excerpt

Genetic factors can influence cardiovascular disease (CVD) risk through multiple behavioural and physiological mechanisms, including lipid metabolism, blood pressure regulation, and inflammatory responses. The present narrative review examines the impact of physical activity on the relationship between genetic susceptibility and CVD risk. Specifically, we synthesize evidence regarding gene-physical activity...

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PMID: 40513105
DOI: 10.1093/eurjpc/zwaf348

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