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Cardiorespiratory Fitness, Genetic Risk, and Incident Atherosclerotic Cardiovascular Events: A Prospective Cohort Study.

Mayo Clinic proceedings - 1 May 2026

Collings Paul J, Wang Mengyao, Chen Ziyuan, Shi Qiaoxin, Luo Shan, Au Yeung Shiu Lun, Gonzales Tomas I, Sharp Stephen J, Brage Søren, Kim Youngwon

Abstract excerpt

OBJECTIVE: To examine the prospective relationship of cardiorespiratory fitness (CRF) with incident atherosclerotic cardiovascular disease (ASCVD) across genetic susceptibility strata. PARTICIPANTS AND METHODS: We conducted a prospective study of 69,447 UK Biobank participants (mean age, 57.6 years; 37,554 [54.1%] female) who performed a fitness test between December 7, 2009, and June 7, 2013. Maximal oxygen...

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Atherosclerosis
Cardiovascular Diseases
Genetic Risk Score
Incidence
Oxygen Consumption

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PMID: 41563160
DOI: 10.1016/j.mayocp.2025.07.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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