Article
A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i).
BMC bioinformatics - 17 Apr 2014
Bermejo-Das-Neves Carlos, Nguyen Hoan-Ngoc, Poch Olivier, Thompson Julie D
Abstract excerpt
BACKGROUND: Small insertion and deletion polymorphisms (Indels) are the second most common mutations in the human genome, after Single Nucleotide Polymorphisms (SNPs). Recent studies have shown that they have significant influence on genetic variation by altering human traits and can cause multiple human diseases. In particular, many Indels that occur in protein coding regions are known to impact the structure or...
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