Back to search

Article

Spike-independent infection of human coronavirus 229E in bat cells

2021-09-27

Abstract excerpt

Bats are the reservoir for numerous human pathogens including coronaviruses. The factors leading to the emergence and sustained transmission of coronaviruses in humans are poorly understood. An outstanding question is how coronaviruses can accomplish a host switch with a likely mismatch between the surface protein spike of a bat virus and the human cellular receptor at the time of zoonotic virus transmission. To i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5bd2baa2-5a8c-5374-86a6-f6b930665bf3
DOI
10.1101/2021.09.18.460924
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Spike-independent infection of human coronavirus 229E in bat cellsDOI 10.1101/2021.09.18.460924
Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronavirusesSemantic proximity
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 bindingSemantic proximity
Conservation analysis of SARS-CoV-2 spike suggests complicated viral adaptation history from bat to humanSemantic proximity
Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus.Semantic proximity
Sequence determinants of human-cell entry identified in ACE2-independent bat sarbecoviruses: A combined laboratory and computational network science approachSemantic proximity
Evolutionary Arms Race between Virus and Host Drives Genetic Diversity in Bat Severe Acute Respiratory Syndrome-Related Coronavirus Spike Genes.Semantic proximity
Contemporary seasonal human coronaviruses display differences in cellular tropism compared to laboratory-adapted reference strainsSemantic proximity
The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competenceSemantic proximity
Identification of within-host deletions in domain 0 of the spike gene of pathogenic feline coronavirus type 2 from the USA.Semantic proximity
The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competence.Semantic proximity
On the Origin of SARS-CoV-2: Did Cell Culture Experiments Lead to Increased Virulence of the Progenitor Virus for Humans?Semantic proximity
Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.Semantic proximity
Select a neighboring publication to make it the new centre.