Article

Contemporary seasonal human coronaviruses display differences in cellular tropism compared to laboratory-adapted reference strains

2025-04-15

Abstract excerpt

Seasonal human coronaviruses (sHCoVs) cause 15-30% of common colds. The reference strains used for research were isolated decades ago and have been passaged extensively but contemporary sHCoVs have been challenging to study as they are notoriously difficult to grow in standard immortalized cell lines. Here we addressed these issues by utilizing primary human nasal epithelial cells (HNECs) and immortalized human br...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6b109cc-87f5-58df-a19a-1aa5a8cc7ef7
DOI: 10.1101/2025.04.13.648626

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Contemporary seasonal human coronaviruses display differences in cellular tropism compared to laboratory-adapted reference strainsDOI 10.1101/2025.04.13.648626Read

Seasonal Human Coronaviruses OC43, 229E, and NL63 Induce Cell Surface Modulation of Entry Receptors and Display Host Cell-Specific Viral Replication KineticsSemantic proximity Read

Seasonal human coronaviruses OC43, 229E, and NL63 induce cell surface modulation of entry receptors and display host cell-specific viral replication kineticsSemantic proximity Read

Isolation and Characterization of Current Human Coronavirus Strains in Primary Human Epithelial Cell Cultures Reveal Differences in Target Cell TropismSemantic proximity Read

A Comparison of Conserved Features in the Human Coronavirus Family Shows That Studies of Viruses Less Pathogenic than SARS-CoV-2, Such as HCoV-OC43, Are Good Model Systems for Elucidating Basic Mechanisms of Infection and Replication in Standard LaboratoriesSemantic proximity Read

Recapitulating infection, thermal sensitivity and antiviral treatment of seasonal coronaviruses in human airway organoidsSemantic proximity Read

Origins and Evolution of Seasonal Human CoronavirusesSemantic proximity Read

Discordant phylodynamic and spatiotemporal transmission patterns driving the long-term persistence and evolution of human coronavirusesSemantic proximity Read

Human coronaviruses: Origin, host and receptorSemantic proximity Read

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expressionSemantic proximity Read

Human Coronavirus OC43 as a Low-Risk Model to Study COVID-19Semantic proximity Read

Adaptation of the endemic coronaviruses HCoV-OC43 and HCoV-229E to the human hostSemantic proximity Read