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Article

The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competence.

PLoS pathogens - 1 Feb 2026

So Ray T Y, Hui Kenrie P Y, Ho John C W, Lau Kaman K M, Zhou Ziqi, Chan Michael C W, Poon Leo L M, Peiris Malik

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus that can cause zoonotic disease in humans with lethal severe viral pneumonia. Dromedary camels are the source of zoonotic infection. As of November 2025, MERS-CoV has resulted in a total of 2630 reported cases, 37% of these being fatal. The number of reported human cases has been on a decreasing trend since 2016 and reached a nadir...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41632817
DOI: 10.1371/journal.ppat.1013336
PMCID: PMC12904574

Genes

DPP4
TMPRSS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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