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Article

Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus.

Journal of virology - 1 Sept 2015

Yang Yang, Liu Chang, Du Lanying, Jiang Shibo, Shi Zhengli, Baric Ralph S, Li Fang

Abstract excerpt

To understand how Middle East respiratory syndrome coronavirus (MERS-CoV) transmitted from bats to humans, we compared the virus surface spikes of MERS-CoV and a related bat coronavirus, HKU4. Although HKU4 spike cannot mediate viral entry into human cells, two mutations enabled it to do so by allowing it to be activated by human proteases. These mutations are present in MERS-CoV spike, explaining why MERS-CoV...

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Identifiers

PMID: 26063432
DOI: 10.1128/JVI.01279-15
PMCID: PMC4524054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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