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Article

Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.

Journal of virology - 1 Jan 2017

Shirato Kazuya, Kanou Kazuhiko, Kawase Miyuki, Matsuyama Shutoku

Abstract excerpt

Human coronavirus 229E (HCoV-229E), a causative agent of the common cold, enters host cells via two distinct pathways: one is mediated by cell surface proteases, particularly transmembrane protease serine 2 (TMPRSS2), and the other by endosomal cathepsin L. Thus, specific inhibitors of these proteases block virus infection. However, it is unclear which of these pathways is actually utilized by HCoV-229E in the...

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Source

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Identifiers

PMID: 27733646
DOI: 10.1128/JVI.01387-16
PMCID: PMC5165181

Genes

TMPRSS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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