Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.

doi:10.1128/JVI.01387-16

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Article

Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.

Journal of virology - 1 Jan 2017

Shirato Kazuya, Kanou Kazuhiko, Kawase Miyuki, Matsuyama Shutoku

Abstract excerpt

Human coronavirus 229E (HCoV-229E), a causative agent of the common cold, enters host cells via two distinct pathways: one is mediated by cell surface proteases, particularly transmembrane protease serine 2 (TMPRSS2), and the other by endosomal cathepsin L. Thus, specific inhibitors of these proteases block virus infection. However, it is unclear which of these pathways is actually utilized by HCoV-229E in the...

Topics

Amino Acid Sequence
Amino Acid Substitution
Biological Evolution
Cathepsin L
Cell Membrane
Common Cold
Coronavirus 229E, Human
Coronavirus Infections
Endocytosis
Endosomes
Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HeLa Cells

Humans

Immune Evasion

Mutation

Protease Inhibitors

Respiratory Mucosa

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 27733646
DOI: 10.1128/JVI.01387-16
PMCID: PMC5165181

Genes

TMPRSS2

Variants

Provenance

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