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Article

A capsid hinge region in European hepatitis E virus links mutations to genotype, virion surface properties, and environmental circulation.

Applied and environmental microbiology - 23 Sept 2026

Kasmi Samy, Sautrey Guillaume, Hartard Cédric, Quilès Fabienne, Bailly Jean-Luc, de Rougemont Alexis, Jeulin Hélène, Duval Raphael E, Gantzer Christophe, Schvoerer Evelyne

Abstract excerpt

Hepatitis E virus (HEV) exhibits genetic diversity associated with distinct public health outcomes and circulation patterns across interconnected human and environmental reservoirs. Most studies have focused on genome-wide diversity, revealing relationships between genotype, virulence, and dissemination routes. However, the role of localized mutations in the capsid protein (ORF2), which may influence the...

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Topics

Hepatitis E virus
Genotype
Humans
Mutation
Capsid Proteins
Virion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Europe

Capsid

Hepatitis E

Viral Proteins

Source

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Identifiers

PMID: 42663480
DOI: 10.1128/aem.01445-26
PMCID: PMC13599484

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