Article

Defining mechanisms of co-inhibitory receptor Lymphocyte Activation Gene-3 (LAG-3) in T cells

2017-01-01

Abstract excerpt

The lymphocyte activation gene-3 (LAG3) inhibitory receptor was first discovered on natural killer cells but has since been shown to also be present on other cells such as activated T cells and B cells. LAG3 is similar to the CD4 receptor and shares a 20% sequence similarity. The ligand of LAG3 has also been determined to be MHCII. Although there is similarity between LAG3 and CD4, LAG3 can bind to MHCII with sign...

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Literature Corpus work: 5bc573bd-81c1-55a2-a0df-ac5d3afdff16
DOI: 10.17638/03014547

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