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Article

LAG-3, a novel lymphocyte activation gene closely related to CD4.

1 May 1990

Abstract excerpt

We have identified a novel human gene of the Ig superfamily, designated LAG-3. Expression of this gene is undetectable in resting PBL, while it is found (a 2-kb message) in activated T and NK cells. The LAG-3 gene includes eight exons; the corresponding cDNA encodes a 498-amino acid membrane protein with four extracellular IgSF domains. The first one belongs to the V-SET; it is particular since it includes an...

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Identifiers

PMID: 1692078
DOI: 10.1084/jem.171.5.1393

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Source receipt: pubmed, retrieved 7 Sept 2026.

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