Article

IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency

2024-01-22

Abstract excerpt

Metabolic dysregulation is one of the most common causes of pediatric neurodegenerative disorders. However, how the disruption of ubiquitous and essential metabolic pathways predominantly affect neural tissue remains unclear. Here we use mouse models of AMPD2 deficiency to study cellular and molecular mechanisms that lead to selective neuronal vulnerability to purine metabolism imbalance. We show that AMPD deficie...

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Identifiers and source

Literature Corpus work: 5bb30057-c8a1-5373-9187-814ec4c1b049
DOI: 10.1101/2024.01.20.576443

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