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Article

IMPDH dysregulation in disease: a mini review.

Biochemical Society transactions - 28 Feb 2022

Burrell Anika L, Kollman Justin M

Abstract excerpt

Inosine-5'-monophosphate dehydrogenase (IMPDH) is a highly conserved enzyme in purine metabolism that is tightly regulated on multiple levels. IMPDH has a critical role in purine biosynthesis, where it regulates flux at the branch point between adenine and guanine nucleotide synthesis, but it also has a role in transcription regulation and other moonlighting functions have been described. Vertebrates have two...

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Source

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Identifiers

PMID: 35191957
DOI: 10.1042/BST20210446
PMCID: PMC9022972

Genes

IMPDH1
IMPDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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