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Article

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions.

eLife - 7 Apr 2020

Plana-Bonamaisó Anna, López-Begines Santiago, Fernández-Justel David, Junza Alexandra, Soler-Tapia Ariadna, Andilla Jordi, Loza-Alvarez Pablo, Rosa Jose Luis, Miralles Esther, Casals Isidre, Yanes Oscar, de la Villa Pedro, Buey Ruben M, Méndez Ana

Abstract excerpt

We report the in vivo regulation of Inosine-5´-monophosphate dehydrogenase 1 (IMPDH1) in the retina. IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP, GDP and GTP. Guanine nucleotide homeostasis is central to photoreceptor cells, where cGMP is the signal transducing molecule in the light response. Mutations in IMPDH1 lead to inherited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32254022
DOI: 10.7554/eLife.56418
PMCID: PMC7176436

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