Article

Host-Derived Localized Acidification Triggers Chaperone-Primed Effector Unfolding at the T3SS Gate

2026-06-02

Abstract excerpt

<title>Abstract</title> <p> Pathogenic bacteria using type Ⅲ secretion system (T3SS) to inject effectors into host cells through a narrow channel, requiring complete substrate unfolding at the point of secretion. However, the regulatory logic integrating host-derived cues to license this decisive conformational switch has remained enigmatic. Here, we discover that host-cell attachment generates a localized acidi...

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Literature Corpus work: 90870602-f4d6-533f-9674-9ee8d8dc09ae
DOI: 10.21203/rs.3.rs-9571766/v1

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Host-Derived Localized Acidification Triggers Chaperone-Primed Effector Unfolding at the T3SS GateDOI 10.21203/rs.3.rs-9571766/v1Read

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