Article
A repulsive electrostatic mechanism for protein export through the type III secretion apparatus.
Biophysical journal - 3 Feb 2010
Rathinavelan Thenmalarchelvi, Zhang Lingling, Picking Wendy L, Weis David D, De Guzman Roberto N, Im Wonpil
Abstract excerpt
Many Gram-negative bacteria initiate infections by injecting effector proteins into host cells through the type III secretion apparatus, which is comprised of a basal body, a needle, and a tip. The needle channel is formed by the assembly of a single needle protein. To explore the export mechanisms of MxiH needle protein through the needle of Shigella flexneri, an essential step during needle assembly, we have...
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