Article

The nuclear oncoprotein SET is necessary for MLL/KMT2A binding and transcriptional elongation

2026-02-28

Abstract excerpt

The nuclear oncoprotein SET (patient “SE” translocation) has been implicated in the etiology of MLL/KMT2A-fusion induced leukemia. Here we examine the details of this dependency in murine, primary hematopoietic cells. Experiments demonstrated Set as downstream target of HoxA9 and a direct interactor of Mll/Kmt2A. Mll/Kmt2A and Set globally co-bound promoter regions. Impairing Set expression induced a metabolic sh...

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Literature Corpus work: 5b928633-5792-5eef-ad6b-6872d705110d
DOI: 10.64898/2026.02.26.708410

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