Article

SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML.

2023-02-16

Abstract excerpt

<h4>Background: </h4> KMT2A -rearranged (KMT2A-R) is an aggressive and chemo-refractory acute leukemia which mostly affects children. Transcriptomics-based characterization and chemical interrogation identified kinases as key drivers of survival and drug resistance in KMT2A -R leukemia. In contrast, the contribution and regulation of phosphatases is unknown. We explored the role of SET, the endogenous inhibitor of...

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Literature Corpus work: 8e3d57b0-7add-5e4e-8f96-97bac2d54a40
DOI: 10.21203/rs.3.rs-2583091/v1

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