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Article

Genome-wide analyses of cell-free DNA for therapeutic monitoring of patients with pancreatic cancer.

Science advances - 23 May 2025

Hruban Carolyn, Bruhm Daniel C, Chen Inna M, Koul Shashikant, Annapragada Akshaya V, Vulpescu Nicholas A, Short Sarah, Theile Susann, Boyapati Kavya, Alipanahi Bahar, Skidmore Zachary L, Leal Alessandro, Cristiano Stephen, Adleff Vilmos, Johannsen Julia S, Scharpf Robert B, Foda Zachariah H, Phallen Jillian, Velculescu Victor E

Abstract excerpt

Determining response to therapy for patients with pancreatic cancer can be challenging. We evaluated methods for assessing therapeutic response using cell-free DNA (cfDNA) in plasma from patients with metastatic pancreatic cancer in the CheckPAC trial (NCT02866383). Patients were evaluated before and after initiation of therapy using tumor-informed plasma whole-genome sequencing (WGMAF) and tumor-independent...

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Identifiers

PMID: 40397745
DOI: 10.1126/sciadv.ads5002
PMCID: PMC12094228

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