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AGE IS ASSOCIATED WITH INCREASED EXPRESSION OF PATTERN RECOGNITION RECEPTOR GENES AND <i>ACE2</i> , THE RECEPTOR FOR SARS-COV-2: IMPLICATIONS FOR THE EPIDEMIOLOGY OF COVID-19 DISEASE

2020-06-16

Abstract excerpt

Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2 , the receptor for SARS-CoV-2. Older age was associated with increased expression of PRR g...

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Literature Corpus work
93d4ecec-bc67-557b-b098-9acd6af577e0
DOI
10.1101/2020.06.15.134403
Open publication

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AGE IS ASSOCIATED WITH INCREASED EXPRESSION OF PATTERN RECOGNITION RECEPTOR GENES AND <i>ACE2</i> , THE RECEPTOR FOR SARS-COV-2: IMPLICATIONS FOR THE EPIDEMIOLOGY OF COVID-19 DISEASEDOI 10.1101/2020.06.15.134403
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