Article

Off-Target MAP2K7 Inhibition Drives the Antileukemic Activity of the PD-1/PD-L1 inhibitor ACS-69 in Pediatric T-ALL

2026-08-14

Abstract excerpt

<title>Abstract</title> <p> T-cell acute lymphoblastic leukemia (T-ALL) remains a high-risk pediatric malignancy characterized by aggressive disease behavior and poor outcomes after relapse, underscoring the need for novel targeted therapies. Our group reported that aberrant activation of the MAP2K7–JNK signaling axis is implicated in T-ALL pathogenesis, promoting leukemic cell survival, proliferation, and treat...

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Literature Corpus work: 5b5822ca-325c-5625-a3b9-6b9e055dc60d
DOI: 10.21203/rs.3.rs-10474945/v1

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