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Article

Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.

Cytometry. Part B, Clinical cytometry - 1 Nov 2020

Bonaccorso Paola, Bugarin Cristina, Buracchi Chiara, Fazio Grazia, Biondi Andrea, Lo Nigro Luca, Gaipa Giuseppe

Abstract excerpt

BACKGROUND: The PI3K/Akt/mTOR (PI3K) signaling pathway has a crucial role in T-cell acute lymphoblastic leukemias (T-ALLs). Although loss-of-function of phosphatase and tensin homolog (PTEN) is a common event in pediatric T-ALLs, the exact role of this tumor suppressor in T-ALL development has yet to be defined. METHODS: Here, we report an optimized cytometric method for accurate proteomic profiling of T-ALL...

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PMID: 32479694
DOI: 10.1002/cyto.b.21882

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