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Article

Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation.

International journal of molecular sciences - 11 Nov 2021

Ayala-Marin Yoshira M, Grant Alice H, Rodriguez Georgialina, Kirken Robert A

Abstract excerpt

Compared to other ethnicities, Hispanic children incur the highest rates of leukemia, and most cases are diagnosed as Acute Lymphoblastic Leukemia (ALL). Despite improved treatment and survival for ALL, disproportionate health outcomes in Hispanics persist. Thus, it is essential to identify oncogenic mutations within this demographic to aid in the development of new strategies to diagnose and treat ALL. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34830095
DOI: 10.3390/ijms222212210
PMCID: PMC8618549

Genes

MAP2K3

Variants

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