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Article

Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a.

Cell cycle (Georgetown, Tex.) - 1 Jul 2012

Buontempo Francesca, Chiarini Francesca, Bressanin Daniela, Tabellini Giovanna, Melchionda Fraia, Pession Andrea, Fini Milena, Neri Luca M, McCubrey James A, Martelli Alberto M

Abstract excerpt

Several lines of evidence suggest that the IκB kinase (IKK)/nuclear factor-κB (NFκB) axis is required for viability of leukemic cells and is a predictor of relapse in T-cell acute lymphoblastic leukemia (T-ALL). Moreover, many anticancer agents induce NFκB nuclear translocation and activation of its target genes, which counteract cellular resistance to chemotherapeutic drugs. Therefore, the design and the study...

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PMID: 22713244
DOI: 10.4161/cc.20859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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