Article

Beyond Base Camp: Promise and Pitfalls of PI3K/mTOR Inhibition in Pediatric High- Grade Gliomas

2025-05-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> High-grade gliomas (HGGs), including diffuse midline glioma (DMG), represent the most aggressive and deadly pediatric brain cancers. Despite recent advances in understanding their molecular underpinnings, these tumors remain universally fatal. A hallmark feature of pediatric HGGs is the frequent presence of mutations and amplifications in components of the phosph...

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Literature Corpus work: 61fce683-376d-5389-83e9-2fbadd6eb353
DOI: 10.21203/rs.3.rs-6508597/v1

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