Article

Mutation of KCNJ5 induced adrenal aldosterone adenoma via CYP11A1 regulation

2025-07-02

Abstract excerpt

<title>Abstract</title> <p>Primary aldosteronism (PA), also known as Conn’s syndrome or adrenal aldosterone producing adenoma (APA), is predominantly caused by functional adrenal tumors and is a common cause of secondary hypertension. The KCNJ5 gene mutations are frequently associated with APA, leading to increased aldosterone production. This study investigates the effect of KCNJ5 mutations on CYP11A1 and the al...

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Literature Corpus work: 5b534886-f0b8-55e2-9948-5b526436da43
DOI: 10.21203/rs.3.rs-6215564/v1

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