Article
New insights into aldosterone-producing adenomas and hereditary aldosteronism: mutations in the K+ channel KCNJ5.
Current opinion in nephrology and hypertension - 1 Mar 2013
Scholl Ute I, Lifton Richard P
Abstract excerpt
PURPOSE OF REVIEW: Primary aldosteronism is a major cause of secondary hypertension worldwide. This review describes the recent studies that have provided dramatic new insight into the pathogenesis of aldosterone-producing adenomas (APAs) and inherited primary aldosteronism, revealing the role of mutations in the potassium channel KCNJ5 in these disorders. RECENT FINDINGS: Either of two somatic gain-of-function...
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