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Article

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function

6 Nov 2023

Abstract excerpt

Crosstalk between cancer and stellate cells is pivotal in pancreatic cancer, resulting in differentiation of stellate cells into myofibroblasts that drives tumour progression. To assess cooperative mechanisms in a 3D context, we generated chimeric spheroids using human and mouse cancer and stellate cells. Species-specific deconvolution of bulk-RNA sequencing data revealed cell type-specific transcriptomes...

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PMID: 37929635
DOI: 10.1002/path.6214

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