Article

BCOR Mutations Define a Therapeutic Vulnerability to DHODH Inhibition in Acute Myeloid Leukemia

2025-09-15

Abstract excerpt

<title>Abstract</title> <p> Acute Myeloid Leukemia (AML) remains challenging to treat, especially in cases with mutations in the BCL-6 co-repressor (BCOR), which are associated with poor prognosis and chemo-resistance. In this study, we reveal a synthetic lethal interaction between <italic>BCOR</italic> and dihydroorotate dehydrogenase (DHODH). We demonstrate that <italic>BCOR</italic> -deficient cells have...

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Literature Corpus work: 2230699a-2801-5129-a261-6645f3b69a4e
DOI: 10.21203/rs.3.rs-7470212/v1

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