Article

A longevity-associated ubiquitin E3 ligase UBE3C governs lamin B1 homeostasis through selective autophagy and delay senescence

2026-08-06

Abstract excerpt

Nuclear lamina integrity is fundamental to cellular homeostasis across the lifespan 1 , and its progressive deterioration is closely linked to human aging 2 . Yet, the regulatory mechanism that govern this decline and how they might be counteracted in long-lived individuals remain poorly defined. Here, by combining whole-exome sequencing of Ashkenazi Jewish centenarians with GTEx transcriptomes, we identify ubiq...

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Literature Corpus work: 9953c628-dc07-5f41-8a92-9fd77ef5cc8f
DOI: 10.64898/2026.08.05.741138

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