Article

Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases

2015-11-06

Abstract excerpt

Shared genetic architecture between phenotypes may be driven by a common genetic basis (pleiotropy) or a subset of genetically similar individuals (heterogeneity). We developed BUHMBOX, a well-powered statistical method to distinguish pleiotropy from heterogeneity using genotype data. We observed a shared genetic basis between 11 of 17 tested autoimmune diseases and type I diabetes (T1D, p<10 12) and 11 of 17 test...

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Literature Corpus work: 5a9bb571-f54f-5cbc-b568-75aa33b5f3dc
DOI: 10.1101/030783

Open publication

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