Article
Population genetics models of common diseases.
Current opinion in genetics & development - 1 Dec 2006
Di Rienzo Anna
Abstract excerpt
The number and frequency of susceptibility alleles for common diseases are important factors to consider in the efficient design of disease association studies. These quantities are the results of the joint effects of mutation, genetic drift and selection. Hence, population genetics models, informed by empirical knowledge about patterns of disease variation, can be used to make predictions about the allelic...
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