Article

Lipid mobilization establishes metabolic tolerance and prevents autonomic collapse in infection

2026-04-21

Abstract excerpt

Survival during infection depends on both pathogen clearance and the ability to tolerate infection-induced physiological changes. Metabolic adaptations are a central component of this tolerance, but the mechanisms underlying these responses remain incompletely defined. Here, we identify white adipose tissue (WAT) lipolysis as a central regulator of metabolic tolerance to infection. In patients with sepsis, higher...

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Literature Corpus work: 5a81e0a1-6897-5603-a342-0f61e97fd675
DOI: 10.64898/2026.04.16.717052

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