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Article

Age-dependent disease tolerance to SARS-CoV-2 infection

2026-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Disease tolerance limits infectious disease severity through tissue damage control mechanisms that do not target pathogens directly. Here we demonstrate that age-dependent decline in adipose tissue lipolysis compromises disease tolerance to SARS-CoV-2 infection. Young adult mice exhibited robust adipocyte lipolysis and 80% survival, whereas old mice showed impaired adipocyte lipolysis and only 2...

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Identifiers and source

Literature Corpus work
cb776006-d332-54db-a9e6-b38400c6368c
DOI
10.64898/2026.06.27.734955
Open publication

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Age-dependent disease tolerance to SARS-CoV-2 infectionDOI 10.64898/2026.06.27.734955
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