Article

Se-Glargine II. Native Function of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge

2023-06-24

Abstract excerpt

Insulin glargine, the active component of basal clinical pharmaceutical formulations Lantus® and Toujeo® (Sanofi), provides a model for principles of therapeutic protein design. Formulated in solution at pH 4, insulin glargine exhibits a shifted isoelectric point (from pH 5.3 to neutral pH) due to a basic dipeptide B-chain extension (Arg B31 -Arg B32 ). In the first article in this series, we described pairwise...

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Literature Corpus work: 5a2a09e6-a25e-5bbb-977c-3c1223c13938
DOI: 10.1101/2023.06.24.546337

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