Article

Se-Glargine I. Chemical Synthesis of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge

2023-06-24

Abstract excerpt

Insulin, a small globular protein, has long provided a model for studies of biophysical principles with therapeutic application. The safety and efficacy of insulin replacement therapy for the treatment for diabetes mellitus have been enhanced by protein engineering. Here, we describe the chemical synthesis of a basal insulin analog stabilized by the substitution of an internal cystine (A6-A11) by a diselenide brid...

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Literature Corpus work: 1dc4ae81-0a75-5734-b9fb-b080eeb0945a
DOI: 10.1101/2023.06.23.546304

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