Role of disulfide bonds in the structure and activity of human insulin.

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Article

Role of disulfide bonds in the structure and activity of human insulin.

Molecules and cells - 31 Dec 2003

Chang Seung-Gu, Choi Ki-Doo, Jang Seung-Hwan, Shin Hang-Cheol

Abstract excerpt

Insulin contains two inter-chain disulfide bonds between the A and B chains (A7-B7 and A20-B19), and one intra-chain linkage in the A chain (A6-A11). To investigate the role of each disulfide bond in the structure, function and stability of the molecule, three des mutants of human insulin, each lacking one of the three disulfide bonds, were prepared by enzymatic conversion of refolded mini-proinsulins. Structural...

Topics

Chromatography, High Pressure Liquid
Circular Dichroism
Cystine
Electrophoresis, Polyacrylamide Gel
Humans
Insulin
Mutation
Proinsulin
Protein Binding
Protein Folding
Receptor, Insulin

Source

Open in PubMed

Identifiers

PMID: 14744022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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