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Article

Fused in sarcoma regulates glutamate signaling and oxidative stress response.

Free radical biology & medicine - 1 Jan 2024

Wong Chiong-Hee, Rahat Abu, Chang Howard C

Abstract excerpt

Mutations in fused in sarcoma (fust-1) are linked to ALS. However, how these ALS causative mutations alter physiological processes and lead to the onset of ALS remains largely unknown. By obtaining humanized fust-1 ALS mutations via CRISPR-CAS9, we generated a C. elegans ALS model. Homozygous fust-1 ALS mutant and fust-1 deletion animals are viable in C. elegans. This allows us to better characterize the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38007141
DOI: 10.1016/j.freeradbiomed.2023.11.015
PMCID: PMC10872661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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