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Article

Lessons from fragile X regarding neurobiology, autism, and neurodegeneration.

Journal of developmental and behavioral pediatrics : JDBP - 1 Feb 2006

Hagerman Randi J

Abstract excerpt

The fragile X mental retardation 1 gene (FMR1) mutation causes two disorders: fragile X syndrome (FXS) in those with the full mutation and the fragile X-associated tremor/ataxia syndrome (FXTAS) in some older individuals with the premutation. FXS is caused by a deficiency of the FMR1 protein (FMRP) leading to dysregulation of many genes that create a phenotype with ADHD, anxiety, and autism. FXTAS is caused by...

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Source

Identifiers

PMID: 16511373
DOI: 10.1097/00004703-200602000-00012

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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