Article

The balance between shear flow and extracellular matrix in ovarian cancer-on-chip

2023-07-23

Abstract excerpt

Ovarian cancer is the most lethal gynecologic cancer in developed countries. Silent onset of the metastatic activity of ovarian tumor cells is factor for poor outcomes. In the tumor microenvironment, the extracellular matrix (ECM) and flow shear stress are known to play key roles in directing cell invasion. Hence, acute and tunable tools are critical to mimic scaffold and fluid for building clinically relevant in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a1c27d2-4c6a-5c8a-9066-4ac7758d2e93
DOI: 10.1101/2023.07.20.549914

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The balance between shear flow and extracellular matrix in ovarian cancer-on-chipDOI 10.1101/2023.07.20.549914Read

Interstitial flows promote amoeboid over mesenchymal motility of breast cancer cells revealed by a three dimensional microfluidic model.Semantic proximity Read

A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+ breast cancer cellsSemantic proximity Read

Shear Stress-Induced Pre-Cytokinetic Block: A New Cellular Response Revealed by an Innovative Shear Stress GeneratorSemantic proximity Read

Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes genomic instabilitySemantic proximity Read

Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote Ovarian Cancer MalignancySemantic proximity Read

A biomimetic model of 3D fluid extracellular macromolecular crowding microenvironment fine-tunes ovarian cancer cells dissemination phenotype.Semantic proximity Read

Tumor-on-chip platforms for transport phenotyping: decoding CAF-driven barriers to drug delivery.Semantic proximity Read

A Human Organotypic Microfluidic Tumor Model Permits Investigation of the Interplay between Patient-Derived Fibroblasts and Breast Cancer CellsSemantic proximity Read

Investigating the impact of the interstitial fluid flow and hypoxia interface on cancer biology using a spheroid-on-chip perfusion systemSemantic proximity Read

The mechanical anisotropy of adipose tissues regulates ovarian cancer invasionSemantic proximity Read

Mechanical activation and expression of HSP27 in epithelial ovarian cancerSemantic proximity Read

Gene expression-phenotype association study reveals the dual role of TNF-α/TNFR1 signaling axis in confined breast cancer cell migration.Semantic proximity Read