Article

Investigating the impact of the interstitial fluid flow and hypoxia interface on cancer biology using a spheroid-on-chip perfusion system

2024-08-22

Abstract excerpt

Solid tumours are complex and heterogeneous systems, which exist in a dynamic biophysical microenvironment. Conventional cancer research methods have long relied on two-dimensional (2D) static cultures which neglect the dynamic, three-dimensional (3D) nature of the biophysical tumour microenvironment (TME), especially the role and impact of interstitial fluid flow (IFF). To address this, we undertook a transcripto...

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Identifiers and source

Literature Corpus work: 874a1e94-ce64-5d86-a15b-25a32740d6b5
DOI: 10.1101/2024.08.21.608919

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