Article

Monocytes Strongly Induce (MYO)Fibroblast Contraction in a New 3D Skin Model to Understand the Inflammation-Fibrosis Axis in Systemic Sclerosis

2026-02-14

Abstract excerpt

<h4>ABSTRACT</h4> Systemic sclerosis (SSc) is an autoimmune disease characterized by excessive fibrosis and tissue stiffness, in which monocytes and macrophages are increasingly recognized as key contributors to pro-fibrotic myofibroblast formation and activation, although the underlying mechanisms remain incompletely understood. Here, we used a three-dimensional (3D) skin model to study how CD14 + monocytes, M1...

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Literature Corpus work: 59e1e99e-09d1-5036-9bbc-f9bd72c1e7e0
DOI: 10.64898/2026.02.12.705496

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