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Article

Lentiviral vectors bearing the cardiac promoter of the Na+-Ca2+ exchanger report cardiogenic differentiation in stem cells.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2008

Barth Andreas S, Kizana Eddy, Smith Rachel R, Terrovitis John, Dong Peihong, Leppo Michelle K, Zhang Yiqiang, Miake Junichiro, Olson Eric N, Schneider Jay W, Abraham M Roselle, Marbán Eduardo

Abstract excerpt

Cardiosphere-derived resident cardiac stem cells (CDCs) are readily isolated from adult hearts and confer functional benefit in animal models of heart failure. To study cardiogenic differentiation in CDCs, we developed a method to genetically label and selectively enrich for cells that have acquired a cardiac phenotype. Lentiviral vectors achieved significantly higher transduction efficiencies in CDCs than any of...

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Identifiers

PMID: 18388932
DOI: 10.1038/mt.2008.30
PMCID: PMC2717010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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