Article

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways

2025-11-17

Abstract excerpt

<h4>SUMMARY</h4> Pathogens deploy effector proteins to exploit host cell biology, and most pathogen open reading frames (ORFs) are rapidly evolving and lack functional annotation. We developed the eORFeome, a scalable functional genomics platform encompassing 3,835 effector ORFs from diverse viruses, bacteria, and parasites. High-throughput barcoded screens across NFκB, apoptosis, p53, cGAS–STING and MHC-I pathwa...

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Identifiers and source

Literature Corpus work: 81c6b36d-3dfc-5ffc-ae01-a4108f88a4f7
DOI: 10.1101/2025.11.17.687821

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