Article
Functional germline variants in DNA damage repair pathways are associated with altered survival in adults with glioma treated with temozolomide.
Neuro-oncology - 21 Jun 2025
Guerra Geno, Wendt George, McCoy Lucie, Hansen Helen M, Kachuri Linda, Molinaro Annette M, Rice Terri, Guan Victoria, Capistrano Lianne, Hsieh Allison, Kalsi Veruna, Sallee Jaimie, Taylor Jennie W, Clarke Jennifer L, Almaraz Eduardo Rodriguez, Wiencke John K, Eckel-Passow Jeanette E, Jenkins Robert B, Wrensch Margaret, Francis Stephen S
Abstract excerpt
BACKGROUND: Temozolomide (TMZ) treatment has demonstrated a variable impact on glioma prognosis. This study examines associations of survival with DNA repair gene germline polymorphisms among glioma patients who did and did not have TMZ treatment. Identifying genetic markers which sensitize tumor cells to TMZ could personalize therapy and improve outcomes. METHODS: We evaluated TMZ-related survival associations...
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