New Pathogenic Germline Variants in Very Early Onset and Familial Colorectal Cancer Patients

Abstract excerpt

A genetic diagnosis facilitates personalized cancer treatment and clinical care of relatives at risk, however, although 25% of colorectal cancer cases are familial, around 95% of the families are genetically unresolved. In this study we performed gene panel analysis on germline DNA of thirty-two established or candidate colorectal cancer predisposing genes in 149 individuals from either families with an...

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