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Depletion of neurocan in the prefrontal cortex impairs temporal order recognition, cognitive flexibility and perisomatic GABAergic innervation

2026-02-10

Abstract excerpt

<title>Abstract</title> <p> The condensed form of neural extracellular matrix (ECM), called perineuronal nets (PNNs), is predominantly associated with parvalbumin-expressing (PV+) interneurons in the cortex and hippocampus. PNNs are enriched in several lecticans, including neurocan (Ncan). A polymorphism in the human <italic>Ncan</italic> gene has been associated with alterations in hippocampus-dependent memor...

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Literature Corpus work
59a07a73-c916-5137-b722-202b208a5559
DOI
10.21203/rs.3.rs-8502638/v1
Open publication

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Depletion of neurocan in the prefrontal cortex impairs temporal order recognition, cognitive flexibility and perisomatic GABAergic innervationDOI 10.21203/rs.3.rs-8502638/v1
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